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Computational identification of miRNAs in threespine stickleback

posted Jan 12, 2014, 1:54 PM by James Cai   [ updated Feb 14, 2014, 3:22 PM ]
A new article is published in Molecular Ecology ResourcesChaturvedi et al. predicted 1,486 mature miRNAs using the homology based miRNA prediction approach. They then performed functional annotation and enrichment analysis of these targets, which identified over-represented motifs. Further, a database resource (GAmiRdb) has been developed for dynamically searching miRNAs and their targets exclusively in three-spined stickleback. Finally, the database was used in two case studies focusing on freshwater adaptation in natural populations. In the first study, they found 44 genomic regions overlapping with predicted miRNA targets. In the second study, they identified two SNPs altering the MRE seed site of sperm-specific glyceraldehyde-3-phosphate gene. [Read on...]